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The Problem

The Opioid Epidemic

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Opioid overdose
deaths in the US

2.7M

suffered from an opioid
use disorder in 2020

#1

cause of death among
18-45 year-olds in the US

500K

have died from opioid overdose over the past decade

30%

of people who needed treatment received it in 2017

Limited treatment modalities continue to be a significant barrier in the mitigation of opioid use disorder

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Limitations of Present Technology

Methadone, Buprenorphine, Naltrexone

Synthetic opioid agonists that bind to opioid receptors and alleviate withdrawal symptoms, prevent drug cravings, and blunt the effects of other opioids

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Limitations:

  • Inherent risk of abuse

  • Undesired side effects

  • Low patient compliance

  • Lack of accessibility

  • Daily clinic visits required

Naloxone

Opioid overdose-reversal medication, restores normal breathing by binding to opioid receptors and reversing the effects of other opioids in the brain

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Limitations:

  • Undesirable withdrawal symptoms

  • Must be administered rapidly

  • Often unavailable or administered too late

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50% of people on current treatment medications relapse within just

6 months

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