The Problem
Today there exists no cure for patients who are chronically infected with Hepatitis B Virus (HBV). Patients may not even realize they carry HBV for decades, but during this time the virus can integrate into the DNA of their liver cells, leading to liver fibrosis, liver cirrhosis, end-stage liver disease, liver cancer, and death.
Although there is a vaccine for HBV, it will only protect from a FUTURE infection. The vaccine does NOT help treat a patient who is already infected with HBV. In addition, 3 injections of the vaccine over 6 months are required for full protection, making it less convenient for those in rural communities and developing countries.
Current approved treatments for HBV temporarily pause viral replication, but do not provide a true cure. Antiviral drugs also require lifelong daily dosing. If a patient forgets to take his or her antiviral medication, HBV can reactivate and accelerate a patient's progression towards potentially fatal liver disease and cancer.