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History of HBV Treatments

Medical treatments for chronic HBV today include highly toxic interferon and lifelong, daily antiviral drugs. Interferon boosts the patient's immune system to fight the infection, but has significant side effects. After years of interferon injections, only 2 - 4% of patients have a "functional cure" which is defined as loss of the HBV protein, HBsAg. This is not a  true "absolute cure" as reservoirs of HBV DNA persist in patient's liver cells and can be reactivated. Antiviral drugs only pause HBV replication on a daily basis and do not even provide a functional cure. If a patient forgets to take his or her daily antiviral medication, HBV can be reactivated immediately. In contrast, our proposed treatment, Hepativir-B, would provide a true, absolute cure, removing all HBV from infected liver cells including all reservoirs of HBV DNA.

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