PROTEIN SYNTHESIS: AUTOMATED FLOW CHEMISTRY
Automated flow chemistry is a novel process developed to rapidly produce proteins de novo. A flow-based solid-phase peptide synthesis method, automated flow chemistry utilizes high-performance liquid chromatography (HPLC) pumps to quickly and effectively deliver chemical reagents and catalyze the binding of amino acids at a rate of 25 peptide bonds per hour.
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APPLICATION AND BENEFITS IN LYSIN THERAPY
Artificial synthesis of lysins in parallel using automated flow chemistry can significantly reduce the quantity of resources necessary to produce on-demand treatments for a variety of bacterial infections.
LIMITATIONS
Due to the low accuracy of automated flow chemistry when forming bonds > 50 amino acids in length and the presence of unpredictable loop region structures connecting the N-terminals and C-terminals, current technology is unable to produce functional lysins.