BREAKTHROUGHS IN PROTEIN SYNTHESIS
AUTOMATED FLOW CHEMISTRY IN LYSIN THERAPY
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After receiving the amino acid sequences outputted by both the sequence and loop region generators, a lysin can be artificially synthesized through automated flow chemistry without the need for bacteriophage cultivation or a pre-existing lysin bank.
The two domains (C and N terminals) are produced separately and in parallel for each lysin, cutting manufacturing time in half. A loop region is then synthesized, connecting the two terminals. Lysin domains are on average 120 amino acids in length, and at a rate of 25 bonds an hour, can be produced in just under 6 hours for rapid, on-demand treatment.
WHAT ARE THE BREAKTHROUGHS NECESSARY?
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Currently, automated flow chemistry is unable to consistently produce functional lysins due to the length of the amino acid sequences and the presence of loop regions. Breakthrough technology must exist to increase the efficiency rate of forming peptide bonds to approximately 100% and allow flow chemistry to accurately produce loop regions.
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