NANOSPROUT
THE TREATMENT OF REMYELINATION USING NANOTECHNOLOGY
About Our Nanotech
Our nanotech will have three main components:
(1)
The insulin receptor binding antibody would allow the nanoparticle to mimic the hormone and move across the barrier using carrier-mediated transport.
(2)
Once past the blood-brain barrier, the second antibody receptor will bind to a ligand found only in oligodendrocytes, called ermin.
(3)
Cytokine antibodies would then neutralize inflammatory cytokines. The drugs Miconazole and Clobetasol will stimulate remyelination.
What is our nanotech made of?
The nanosphere will be composed of modified human serum albumins and contain antibodies for cytokines, miconazole, and clobetasol. The nanoparticle is made from poly(hexadecyl cyanoacrylate) which will cross the blood-brain barrier and is biodegradable. If the nanoparticle is too big to pass the blood-brain barrier, we are able to use the insulin receptor.
Framework
Taking inspiration from the cobra weaving exploding stick bomb, our nanotech’s shell is be created such that the weaving is in a spherical shape.
Content Release
The shell will ‘explode’ and release its content whenever the brain ligand-receptor bind to a ligand found in oligodendrocytes, called ermin. Whenever the receptor binds, the receptor expands like a wedge, such that one of the weaving is broken; this causes a chain reaction.