Bibliography

**ALL IMAGES AND ANIMATION ARE DRAWN BY YEHSHIN MOON**

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Bagley, Christopher J., et al. “The Structural and Functional Basis of Cytokine Receptor Activation: Lessons from the Common β Subunit of the Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-3 (IL-3), and IL-5 Receptors.” Blood, American Society of Hematology, 1 Mar. 1997, https://ashpublications.org/blood/article/89/5/1471/236292/The-Structural-and-Functional-Basis-of-Cytokine. 

---

Bayda, Samer, et al. “The History of Nanoscience and Nanotechnology: From Chemical-Physical Applications to Nanomedicine.” Molecules (Basel, Switzerland), MDPI, 27 Dec. 2019, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982820/#B6-molecules-25-00112. 

---

Bosetti, Rita, and Stephen L Jones. “Cost-effectiveness of nanomedicine: estimating the real size of nano-costs.” Nanomedicine (London, England) vol. 14,11 (2019): 1367-1370. doi:10.2217/nnm-2019-0130 

---

Brockschnieder, Damian, et al. “Ermin, a Myelinating Oligodendrocyte-Specific Protein That Regulates Cell Morphology.” Journal of Neuroscience, Society for Neuroscience, 18 Jan. 2006, https://www.jneurosci.org/content/26/3/757#:~:text=Oligodendrocytes%20form%20an%20insulating%20multilamellar,rapid%20propagation%20of%20action%20potentials.&text=This%20effort%20resulted%20in%20the,is%20exclusively%20expressed%20by%20oligodendrocytes. 

---

Brune, Synne, et al. “LesionQuant for Assessment of MRI in Multiple Sclerosis-A Promising Supplement to the Visual Scan Inspection.” Frontiers, Frontiers, 1 Jan. 1AD, https://www.frontiersin.org/articles/10.3389/fneur.2020.546744/full. 

---

“Current Advancements in Promoting ... - Sage Journals.” SAGE Journals, 1 Oct. 2018, https://journals.sagepub.com/doi/full/10.1177/1352458518800827. 

---

“Definition of Ms.” National Multiple Sclerosis Society, https://www.nationalmssociety.org/What-is-MS/Definition-of-MS. 

---

“Detection, Analysis of 'Cell Dust' May Allow Diagnosis, Monitoring of Brain Cancer.” Method for Early Diagnosis of Brain Cancer under Development Using Magnetic Nanoparticles and Nuclear Magnetic Resonance Technology, 11 Nov. 2012, https://www.understandingnano.com/brain-cancer-diagnosis-magnetic-nanoparticles.html. 

---

“Drugs That Promote Remyelination Could Help Treat Multiple Sclerosis.” Neuronline, 7 Nov. 2016, https://neuronline.sfn.org/scientific-research/drugs-that-promote-remyelination-could-help-treat-multiple-sclerosis. 

---

Ellis, Rachel Reiff. “Demyelinating Disorders: Types, Causers, Symptoms, Treatments.” WebMD, WebMD, 9 Aug. 2020, https://www.webmd.com/multiple-sclerosis/what-are-demyelinating-disorders. 

---

Emeje, Martins Ochubiojo, et al. “Nanotechnology in Drug Delivery.” IntechOpen, IntechOpen, 31 Oct. 2012, https://www.intechopen.com/chapters/40262. 

---

Feynman, Richard P. Plenty of Room at the Bottom, Pasadena, California, 1959. 

---

“The Future of Cancer Treatment: First-of-Its-Kind Self-Assembled Nanoparticle for Targeted and Triggered Thermo-Chemotherapy.” Nanorods Used in Thermo-Chemotherapy against Cancer Cells, 18 Oct. 2012, https://www.understandingnano.com/nanorod-thermo-chemotherapy.html. 

---

Heidi Moawad, MD. “Demyelination as a Cause of Neurological Disease.” Verywell Health, Verywell Health, 21 Sept. 2021, https://www.verywellhealth.com/demyelination-4691934. 

---

“History of Multiple Sclerosis.” MSAA, 26 Feb. 2020, https://mymsaa.org/ms-information/overview/history/. 

---

Kjetil Bjornevik, Marianna Cortese, Brian C. Healy, Jens Kuhle, Michael J. Mina, Yumei Leng, Stephen J. Elledge, David W. Niebuhr, Ann I. Scher, Kassandra L. Munger, Alberto Ascherio, "Epstein-Barr virus may be leading cause of multiple sclerosis", Science, January 13, 2022, doi: 10.1126/science.abj8222 

---

Kou, Longfa, et al. “The Endocytosis and Intracellular Fate of Nanomedicines: Implication for Rational Design.” Asian Journal of Pharmaceutical Sciences, Elsevier, 21 Aug. 2013, https://www.sciencedirect.com/science/article/pii/S1818087613000020. 

---

Kumar, David R, et al. “Jean-Martin Charcot: The Father of Neurology.” Clinical Medicine & Research, Marshfield Clinic, 9 Mar. 2011, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064755/. 

---

Liu, Ziteng, and Ying Ying. “The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia.” Frontiers in Cell and Developmental Biology, Frontiers Media S.A., 12 June 2020, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303286/. 

---

Martin, Cory. “The History of Multiple Sclerosis.” Verywell Health, https://www.verywellhealth.com/what-is-the-history-of-multiple-sclerosis-5199934. 

---

Morita, Yoshitsugu, et al. “Protein Nanoparticles Formed by Self-Assembly of Human Serum Albumin with a Fatty Acid Arm.” Chemistry Letters, 20 Nov. 2019, https://www.journal.csj.jp/doi/10.1246/cl.190785. 

---

“MS Symptoms.” National Multiple Sclerosis Society, https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms. 

---

“Multiple Sclerosis.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 7 Jan. 2022, https://www.mayoclinic.org/diseases-conditions/multiple-sclerosis/diagnosis-treatment/drc-20350274. 

---

Murnane, Kevin. “Nanotechnology Applications That Can Change the World: Healing the Body.” Forbes, Forbes Magazine, 11 Sept. 2017, https://www.forbes.com/sites/kevinmurnane/2017/09/10/nanotechnology-applications-that-can-change-the-world-healing-the-body/?sh=4d9375a06eef. 

---

National Geographic Society. “Nanotechnology.” National Geographic Society, 20 Aug. 2013, https://www.nationalgeographic.org/encyclopedia/nanotechnology/. 

---

Pardridge, William M. “The Blood-Brain Barrier and Neurotherapeutics.” NeuroRx: the Journal of the American Society for Experimental NeuroTherapeutics, The American Society for Experimental NeuroTherapeutics, Inc., 2 Jan. 2005, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539315/. 

---

PMC, Europe. “Drug-Related Demyelinating Syndromes: Understanding Risk Factors, Pathophysiological Mechanisms and Magnetic Resonance Imaging Findings.” Europe PMC, 21 July 2021, https://europepmc.org/article/med/34332456. 

---

Roco, Mihail C. “The Long View of Nanotechnology Development: The National Nanotechnology Initiative at 10 Years.” Nanotechnology Research Directions for Societal Needs in 2020, 2011, pp. 1–28., https://doi.org/10.1007/978-94-007-1168-6_1.

---

Su, Shi, and Peter M. Kang. “Systemic Review of Biodegradable Nanomaterials in Nanomedicine.” Nanomaterials, vol. 10, no. 4, 2020, p. 656., https://doi.org/10.3390/nano10040656. ---

Su, Xuewen, et al. “Protective Effect of Miconazole on Rat Myelin Sheaths Following Premature Infant Cerebral White Matter Injury.” Experimental and Therapeutic Medicine, D.A. Spandidos, 15 Mar. 2018, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795799/. 

---

Taghavi, Sayed Mohammad et al. “Effects of Nanoparticles on the Environment and Outdoor Workplaces.” Electronic physician vol. 5,4 706-12. 1 Nov. 2013, doi:10.14661/2013.706-712 

---

TJ., Murray. “History of MS.” MS Trust, 1 Nov. 2018, https://mstrust.org.uk/a-z/history-ms. 

“Understanding MS.” National Multiple Sclerosis Society, https://www.nationalmssociety.org/What-is-MS/MS-FAQ-s. 

---

Warrington, Arthur E et al. “A recombinant human IgM promotes myelin repair after a single, very low dose.” Journal of neuroscience research vol. 85,5 (2007): 967-76. doi:10.1002/jnr.21217 

---

WM, Pardridge. “Tyrosine Hydroxylase Replacement in Experimental Parkinson's Disease with Transvascular Gene Therapy.” NeuroRx: the Journal of the American Society for Experimental NeuroTherapeutics, U.S. National Library of Medicine, 2 Jan. 2005, https://pubmed.ncbi.nlm.nih.gov/15717064/. 

---

Zalc, Bernard. “One Hundred and Fifty Years Ago Charcot Reported Multiple Sclerosis as a New Neurological Disease.” Brain: a Journal of Neurology, Oxford University Press, 1 Dec. 2018, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262215/. 

---

Zhornitsky, Simon et al. “Quetiapine fumarate for the treatment of multiple sclerosis: focus on myelin repair.” CNS neuroscience & therapeutics vol. 19,10 (2013): 737-44. doi:10.1111/cns.12154

---

Zorina, Y., Stricker, J., Caggiano, A.O. et al. Human IgM antibody rHIgM22 promotes phagocytic clearance of myelin debris by microglia. Sci Rep 8, 9392 (2018). https://doi.org/10.1038/s41598-018-27559-y