Use of iPSCs in Alzheimer’s Disease Brain Inflammation
At the age of 45, 25% of women will develop Alzheimer's Disease in their life
In 2024, 116,022 American deaths were a result of Alzheimer's, making it the 6th leading cause of US deaths
In 2024, 116,022 American deaths were a result of Alzherimer's, making it the 6th leading cause of death
DID YOU KNOW?
In 2024, 116,022 American deaths were a result of Alzherimer's, making it the 6th leading cause of death
44.1% of nursing home residents are diagnosed with Alzheimer's
Chronic Brain Inflammation
Alzheimer's (AD) is a progressive neurological disease that causes neurodegeneration. Its risk factor increases with age. It is characterized by the amassment of amyloid plaques and neurofibrillary tangles in the brain.
Chronic brain inflammation (CBI) is a prolonged activation of the neuroimmune system that often occurs from AD.
The Problem of CBI
CBI accelerates the progression of AD significantly as immune cells become overworked and harmful to the neurons around it. This results in fatigue and memory issues. Severe CBI can easily cause death or a coma from the pressure put on the brain stem.
A Positron Emission Tomography (PET) scan of a brain affected by CBI (Jones et al. 2023)
A scan showing the differences between mild, moderate, and severe cases of CBI (Gottesman Lab, 2018)