We need breakthroughs in Artificial Intelligence (AI) and oxygen crystals. 

AI will need to be reliable because life is going to depend on it. The oxygen crystals need to work with the sensors and AI to release the oxygen in order to inflate at the right time. We need to do studies on how to store the crystals in the suit.

 A future breakthrough for our suit would be to use the oxygen to breathe in addition to inflating the suit.